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Differences in Medium-Induced Conformational Plasticity Presumably Underlie Different Cytotoxic Activity of Ricin and Viscumin

Structurally similar catalytic subunits A of ricin (RTA) and viscumin (MLA) exhibit cytotoxic activity through ribosome inactivation. Ricin is more cytotoxic than viscumin, although the molecular mechanisms behind this difference are still poorly understood. To shed more light on this problem, we us...

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Príomhchruthaitheoirí: Pavel Volynsky, Diana Maltseva, Valentin Tabakmakher, Eduard V. Bocharov, Maria Raygorodskaya, Galina Zakharova, Elena Britikova, Alexander Tonevitsky, Roman Efremov
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: MDPI AG 2022-02-01
Sraith:Biomolecules
Ábhair:
Rochtain ar líne:https://www.mdpi.com/2218-273X/12/2/295
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