Differences in Medium-Induced Conformational Plasticity Presumably Underlie Different Cytotoxic Activity of Ricin and Viscumin

Structurally similar catalytic subunits A of ricin (RTA) and viscumin (MLA) exhibit cytotoxic activity through ribosome inactivation. Ricin is more cytotoxic than viscumin, although the molecular mechanisms behind this difference are still poorly understood. To shed more light on this problem, we us...

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Автори:	Pavel Volynsky, Diana Maltseva, Valentin Tabakmakher, Eduard V. Bocharov, Maria Raygorodskaya, Galina Zakharova, Elena Britikova, Alexander Tonevitsky, Roman Efremov
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2022-02-01
Серія:	Biomolecules
Предмети:	membrane trafficking of proteins medium effects on protein structure molecular dynamics type II ribosome inactivating proteins protein–membrane interactions
Онлайн доступ:	https://www.mdpi.com/2218-273X/12/2/295
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