Phosphoproteomics Reveals Selective Regulation of Signaling Pathways by Lysophosphatidic Acid Species in Macrophages

Lysophosphatidic acid (LPA) species, prevalent in the tumor microenvironment (TME), adversely impact various cancers. In ovarian cancer, the 18:0 and 20:4 LPA species are selectively associated with shorter relapse-free survival, indicating distinct effects on cellular signaling networks. Macrophage...

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Главные авторы:	Raimund Dietze, Witold Szymanski, Kaire Ojasalu, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Rolf Müller
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2024-05-01
Серии:	Cells
Предметы:	lysophosphatidic acid macrophages phosphoproteomics RHO/RAC1 signaling cholesterol biosynthesis
Online-ссылка:	https://www.mdpi.com/2073-4409/13/10/810
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