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Phosphoproteomics Reveals Selective Regulation of Signaling Pathways by Lysophosphatidic Acid Species in Macrophages

Lysophosphatidic acid (LPA) species, prevalent in the tumor microenvironment (TME), adversely impact various cancers. In ovarian cancer, the 18:0 and 20:4 LPA species are selectively associated with shorter relapse-free survival, indicating distinct effects on cellular signaling networks. Macrophage...

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Principais autores: Raimund Dietze, Witold Szymanski, Kaire Ojasalu, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Johannes Graumann, Rolf Müller
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-05-01
Serier:Cells
Fag:
lysophosphatidic acid
macrophages
phosphoproteomics
RHO/RAC1 signaling
cholesterol biosynthesis
Online adgang:https://www.mdpi.com/2073-4409/13/10/810
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