Visualizing subcellular changes in the NAD(H) pool size versus redox state using fluorescence lifetime imaging microscopy of NADH

Abstract NADH autofluorescence imaging is a promising approach for visualizing energy metabolism at the single-cell level. However, it is sensitive to the redox ratio and the total NAD(H) amount, which can change independently from each other, for example with aging. Here, we evaluate the potential...

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Bibliografische Detailangaben

Hauptverfasser:	Angela Song, Nicole Zhao, Diana C. Hilpert, Caroline Perry, Joseph A. Baur, Douglas C. Wallace, Patrick M. Schaefer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-04-01
Schriftenreihe:	Communications Biology
Online-Zugang:	https://doi.org/10.1038/s42003-024-06123-7
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