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Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

N6‐methyladenosine (m6A) modifications accelerate microRNA (miRNA) biogenesis by promoting the processing of m6A‐modified primary miRNAs (pri‐miRNAs). However, the regulatory mechanism of m6A modification of pri‐miRNA remains unclear. Here, we found that NF90‐NF45 acts as a negative regulator of the...

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Huvudupphov: Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto
Materialtyp: Artigo
Språk:Inglês
Utgiven: Wiley 2026-05-01
Serie:FEBS Open Bio
Ämnen:
miRNA biogenesis
RNA binding protein
RNA metabolism
RNA methylation
RNA methyltransferase
RNA modification
Länkar:https://doi.org/10.1002/2211-5463.70173
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