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The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma.

BACKGROUND: Despite recent progress, therapy for metastatic clear cell renal cell carcinoma (CCRCC) is still inadequate. Dysregulated Notch signaling in CCRCC contributes to tumor growth, but the full spectrum of downstream processes regulated by Notch in this tumor form is unknown. METHODOLOGY/PRIN...

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Principais autores: Jonas Sjölund, Anna-Karin Boström, David Lindgren, Sugata Manna, Aristidis Moustakas, Börje Ljungberg, Martin Johansson, Erik Fredlund, Håkan Axelson
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2011-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC3149633?pdf=render
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