CNETML: maximum likelihood inference of phylogeny from copy number profiles of multiple samples

Abstract Phylogenetic trees based on copy number profiles from multiple samples of a patient are helpful to understand cancer evolution. Here, we develop a new maximum likelihood method, CNETML, to infer phylogenies from such data. CNETML is the first program to jointly infer the tree topology, node...

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Egile Nagusiak:	Bingxin Lu, Kit Curtius, Trevor A. Graham, Ziheng Yang, Chris P. Barnes
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2023-06-01
Saila:	Genome Biology
Gaiak:	Phylogeny inference Copy number alteration Maximum likelihood Model of evolution Low-coverage sequencing
Sarrera elektronikoa:	https://doi.org/10.1186/s13059-023-02983-0
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