CNETML: maximum likelihood inference of phylogeny from copy number profiles of multiple samples

Abstract Phylogenetic trees based on copy number profiles from multiple samples of a patient are helpful to understand cancer evolution. Here, we develop a new maximum likelihood method, CNETML, to infer phylogenies from such data. CNETML is the first program to jointly infer the tree topology, node...

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Detalles Bibliográficos

Autores principales:	Bingxin Lu, Kit Curtius, Trevor A. Graham, Ziheng Yang, Chris P. Barnes
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2023-06-01
Colección:	Genome Biology
Materias:	Phylogeny inference Copy number alteration Maximum likelihood Model of evolution Low-coverage sequencing
Acceso en línea:	https://doi.org/10.1186/s13059-023-02983-0
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