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Tuina therapy alleviates neuropathic pain by modulating the CX3CL1/CX3CR1 axis to inhibit degradation of the perineuronal nets

IntroductionTuina, a traditional Chinese non-pharmacological therapy, is effective in treating neuropathic pain (NP). However, its underlying molecular mechanisms remain elusive. The degradation of perineuronal nets (PNNs) via the CX3CL1/CX3CR1 axis is a key driver of central sensitization. This stu...

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Principais autores: Yukui Tian, Cheng Wang, Qingguang Zhu, Lei Guo, Xue Bai, Gulaisar Aikebaier, Xiaofeng Cui, Zhiwei Wu, Junchang Liu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-07-01
Serier:Frontiers in Molecular Neuroscience
Fag:
CX3CL1/CX3CR1
neuropathic pain
perineuronal nets
phagocytosis
Tuina
Online adgang:https://www.frontiersin.org/articles/10.3389/fnmol.2026.1860375/full
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