Tuina therapy alleviates neuropathic pain by modulating the CX3CL1/CX3CR1 axis to inhibit degradation of the perineuronal nets

IntroductionTuina, a traditional Chinese non-pharmacological therapy, is effective in treating neuropathic pain (NP). However, its underlying molecular mechanisms remain elusive. The degradation of perineuronal nets (PNNs) via the CX3CL1/CX3CR1 axis is a key driver of central sensitization. This stu...

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Autori principali:	Yukui Tian, Cheng Wang, Qingguang Zhu, Lei Guo, Xue Bai, Gulaisar Aikebaier, Xiaofeng Cui, Zhiwei Wu, Junchang Liu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-07-01
Serie:	Frontiers in Molecular Neuroscience
Soggetti:	CX3CL1/CX3CR1 neuropathic pain perineuronal nets phagocytosis Tuina
Accesso online:	https://www.frontiersin.org/articles/10.3389/fnmol.2026.1860375/full
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