Periostin-mediated activation of NF-κB signaling promotes tumor progression and chemoresistance in glioblastoma

Abstract Glioblastoma (GBM) is the most aggressive form of diffuse glioma, characterized by high lethality. Temozolomide (TMZ)-based chemotherapy is a standard treatment for GBM, but development of chemoresistance poses a significant therapeutic challenge. Despite advances in understanding GBM biolo...

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Bibliografische Detailangaben

Hauptverfasser:	Yu Shang, Yuxia Liang, Beichen Zhang, Wei Wu, Yihao Peng, Jin Wang, Ming Zhang, Chen Niu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-04-01
Schriftenreihe:	Scientific Reports
Schlagworte:	EMT-related phenotypes NF-κB signaling TMZ resistance POSTN Glioblastoma
Online-Zugang:	https://doi.org/10.1038/s41598-025-92969-8
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