Overcoming temozolomide resistance in glioma: recent advances and mechanistic insights
Abstract Temozolomide (TMZ) remains the cornerstone chemotherapy for glioma, yet intrinsic and acquired resistance mechanisms significantly limit its clinical effectiveness. This review summarizes the multifaceted molecular pathways contributing to TMZ resistance, including enhanced DNA repair mecha...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BMC
2025-06-01
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| Col·lecció: | Acta Neuropathologica Communications |
| Matèries: | |
| Accés en línia: | https://doi.org/10.1186/s40478-025-02046-4 |
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