A systematic safety pipeline for selection of T-cell receptors to enter clinical use
Abstract Cancer immunotherapy using T cell receptor-engineered T cells (TCR-Ts) represents a promising treatment option. However, technologies for pre-clinical safety assessment are incomplete or inaccessible to most laboratories. Here, TCR-T off-target reactivity was assessed in five steps: (1) Map...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Portfolio
2023-08-01
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| Schriftenreihe: | npj Vaccines |
| Online-Zugang: | https://doi.org/10.1038/s41541-023-00713-y |
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