Targeting Arginase 1 but Not Arginase 2 Protects from Myocardial Ischemia–Reperfusion Injury via Nitric Oxide Signaling by Red Blood Cells in Type 2 Diabetes

Background: Arginase influences cardiac tolerance to ischemia–reperfusion by modulating nitric oxide (NO) signaling. In type 2 diabetes (T2D), elevated arginase activity may worsen ischemic injury through red blood cells (RBCs), but the specific roles of arginase isoforms are unclear. Methods: C57BL...

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Главные авторы:	Jiangning Yang, Yahor Tratsiakovich, Renhai Cao, Ali Mahdi, Gianluigi Pironti, Tong Jiao, Rawan Humoud, Eftychia Kontidou, John Tengbom, Aida Collado, Zhichao Zhou, Yihai Cao, Eleonore Köhler, Adam E. Mullick, John Pernow
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2026-01-01
Серии:	Antioxidants
Предметы:	arginase nitric oxide ischemic tolerance type 2 diabetes sex
Online-ссылка:	https://www.mdpi.com/2076-3921/15/1/58
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