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Targeting Arginase 1 but Not Arginase 2 Protects from Myocardial Ischemia–Reperfusion Injury via Nitric Oxide Signaling by Red Blood Cells in Type 2 Diabetes

Background: Arginase influences cardiac tolerance to ischemia–reperfusion by modulating nitric oxide (NO) signaling. In type 2 diabetes (T2D), elevated arginase activity may worsen ischemic injury through red blood cells (RBCs), but the specific roles of arginase isoforms are unclear. Methods: C57BL...

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Kaydedildi:
Asıl Yazarlar: Jiangning Yang, Yahor Tratsiakovich, Renhai Cao, Ali Mahdi, Gianluigi Pironti, Tong Jiao, Rawan Humoud, Eftychia Kontidou, John Tengbom, Aida Collado, Zhichao Zhou, Yihai Cao, Eleonore Köhler, Adam E. Mullick, John Pernow
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2026-01-01
Seri Bilgileri:Antioxidants
Konular:
arginase
nitric oxide
ischemic tolerance
type 2 diabetes
sex
Online Erişim:https://www.mdpi.com/2076-3921/15/1/58
Etiketler: Etiketle
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