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Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage

Aminoglycoside-induced hair cell (HC) loss is one of the most important causes of hearing loss. After entering the inner ear, aminoglycosides induce the production of high levels of reactive oxygen species (ROS) that subsequently activate apoptosis in HCs. Citicoline, a nucleoside derivative, plays...

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Autori principali: Zhenhua Zhong, Xiaolong Fu, He Li, Jie Chen, Maohua Wang, Song Gao, Liyan Zhang, Cheng Cheng, Yuan Zhang, Peipei Li, Shasha Zhang, Xiaoyun Qian, Yilai Shu, Renjie Chai, Xia Gao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020-08-01
Serie:Frontiers in Cell and Developmental Biology
Soggetti:
citicoline
hair cell
apoptosis
reactive oxygen species
aminoglycosides
Accesso online:https://www.frontiersin.org/article/10.3389/fcell.2020.00712/full
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