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Pre-treatment With Fasudil Prevents Neomycin-Induced Hair Cell Damage by Reducing the Accumulation of Reactive Oxygen Species

Ototoxic drug-induced hair cell (HC) damage is one of the main causes of sensorineural hearing loss, which is one of the most common sensory disorders in humans. Aminoglycoside antibiotics are common ototoxic drugs, and these can cause the accumulation of intracellular oxygen free radicals and lead...

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Principais autores: Yanqiu Zhang, Wei Li, Zuhong He, Yunfeng Wang, Buwei Shao, Cheng Cheng, Shasha Zhang, Mingliang Tang, Xiaoyun Qian, Weijia Kong, Hui Wang, Renjie Chai, Xia Gao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-11-01
coleção:Frontiers in Molecular Neuroscience
Assuntos:
ototoxic
hair cell
fasudil
aminoglycoside
reactive oxygen species
rho signaling pathway
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnmol.2019.00264/full
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