Elevated levels of damage-associated molecular patterns HMGB1 and S100A8/A9 coupled with toll-like receptor-triggered monocyte activation are associated with inflammation in patients with myelofibrosis

Inflammation plays a pivotal role in the pathogenesis of primary and post-essential thrombocythemia or post-polycythemia vera myelofibrosis (MF) in close cooperation with the underlying molecular drivers. This inflammatory state is induced by a dynamic spectrum of inflammatory cytokines, although re...

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Principais autores:	Geraldine De Luca, Nora P. Goette, Paola R. Lev, Maria C. Baroni Pietto, Cecilia P. Marin Oyarzún, Miguel A. Castro Ríos, Beatriz Moiraghi, Federico Sackmann, Laureano J. Kamiya, Veronica Verri, Victoria Caula, Vanina Fernandez, Angeles Vicente, Julio Pose Cabarcos, Vanesa Caruso, Maria F. Camacho, Irene B. Larripa, Marina Khoury, Rosana F. Marta, Ana C. Glembotsky, Paula G. Heller
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2024-09-01
Serija:	Frontiers in Immunology
Teme:	myelofibrosis monocyte inflammation HMGB1 S100A8/A9 Toll-like receptors
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1365015/full
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