Multiplexed Gel-based ABPP Strategy for Target-agnostic Serine Hydrolase Inhibitor Screening

Serine hydrolases (SHs) represent a functionally defined enzyme class with significant roles in human physiology, yet many of the approximately 240 human SH’s lack selective chemical inhibitors required for functional validation. To address this, we developed a medium throughput screening platform b...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Franciscus H. G. ter Brake, Patrick Rehorst, Machiel W. Henst, Mario van der Stelt, Antonius P. A. Janssen
Format:	Artigo
Jezik:	Alemão
Izdano:	Swiss Chemical Society 2026-03-01
Serija:	CHIMIA
Teme:	ABHD2 Activity-based protein profiling FAAH; Hit-finding Serine hydrolase
Online dostop:	https://www.chimia.ch/chimia/article/view/10219
Oznake:	Označite Brez oznak, prvi označite!