High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

Abstract Background Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP) using fluorophosphonate (FP) probes has been a p...

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Bibliografische gegevens

Hoofdauteurs:	Niina Aaltonen, Prosanta K. Singha, Hermina Jakupović, Thomas Wirth, Haritha Samaranayake, Sanna Pasonen-Seppänen, Kirsi Rilla, Markku Varjosalo, Laura E. Edgington-Mitchell, Paulina Kasperkiewicz, Marcin Drag, Sara Kälvälä, Eemeli Moisio, Juha R. Savinainen, Jarmo T. Laitinen
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2020-03-01
Reeks:	Biological Procedures Online
Onderwerpen:	Activity-based protein profiling (ABPP) Brain cryosection Glioblastoma multiforme (GBM) Immunohistochemistry Serine hydrolase activity Neutrophil serine protease (NSP)
Online toegang:	http://link.springer.com/article/10.1186/s12575-020-00118-4
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