Nuclear 82-kDa choline acetyltransferase decreases amyloidogenic APP metabolism in neurons from APP/PS1 transgenic mice

Alzheimer disease (AD) is associated with increased amyloidogenic processing of amyloid precursor protein (APP) to β-amyloid peptides (Aβ), cholinergic neuron loss with decreased choline acetyltransferase (ChAT) activity, and cognitive dysfunction. Both 69-kDa ChAT and 82-kDa ChAT are expressed in c...

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主要な著者:	Shawn Albers, Fatima Inthathirath, Sandeep K. Gill, Warren Winick-Ng, Ewa Jaworski, Daisy Y.L. Wong, Robert Gros, R. Jane Rylett
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2014-09-01
シリーズ:	Neurobiology of Disease
主題:	Alzheimer disease Amyloid Amyloidogenic BACE1 Cholinergic Choline acetyltransferase
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S0969996114001260
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