Exploring rigid-backbone protein docking in biologics discovery: a test using the DARPin scaffold

Accurate protein-protein docking remains challenging, especially for artificial biologics not coevolved naturally against their protein targets, like antibodies and other engineered scaffolds. We previously developed ProPOSE, an exhaustive docker with full atomistic details, which delivers cutting-e...

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Autors principals:	Francis Gaudreault, Jason Baardsnes, Yuliya Martynova, Aurore Dachon, Hervé Hogues, Christopher R. Corbeil, Enrico O. Purisima, Mélanie Arbour, Traian Sulea
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-08-01
Col·lecció:	Frontiers in Molecular Biosciences
Matèries:	binding affinity protein-protein docking rigid backbone DARPin ProPOSE
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fmolb.2023.1253689/full
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