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Back-to-Germline (B2G) Procedure for Antibody Devolution

Bispecific antibodies (bsAbs) with avidity-enhanced specificity can be used to address target cells with increased specificity, ideally binding efficiently to cells that express two cognate antigens, yet not to cells that express only one of those. Building blocks required to generate such bsAbs are...

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Principais autores: Anja Schrade, Alexander Bujotzek, Christian Spick, Martina Wagner, Johannes Goerl, Xenia Wezler, Guy Georges, Roland E. Kontermann, Ulrich Brinkmann
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2019-08-01
Serier:Antibodies
Fag:
protein engineering
antibody
maturation
affinity
structure
antigen binding
Online adgang:https://www.mdpi.com/2073-4468/8/3/45
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