Topical application of a platelet activating factor receptor agonist suppresses phorbol ester-induced acute and chronic inflammation and has cancer chemopreventive activity in mouse skin.

Platelet activating factor (PAF) has long been associated with acute edema and inflammatory responses. PAF acts by binding to a specific G-protein coupled receptor (PAF-R, Ptafr). However, the role of chronic PAF-R activation on sustained inflammatory responses has been largely ignored. We recently...

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Detalhes bibliográficos

Principais autores:	Ravi P Sahu, Samin Rezania, Jesus A Ocana, Sonia C DaSilva-Arnold, Joshua R Bradish, Justin D Richey, Simon J Warren, Badri Rashid, Jeffrey B Travers, Raymond L Konger
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2014-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC4222871?pdf=render
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