Copper(I)-binding properties of de-coppering drugs for the treatment of Wilson disease. α-Lipoic acid as a potential anti-copper agent

Abstract Wilson disease is an autosomal recessive genetic disorder caused by loss-of-function mutations in the P-type copper ATPase, ATP7B, which leads to toxic accumulation of copper mainly in the liver and brain. Wilson disease is treatable, primarily by copper-chelation therapy, which promotes co...

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Hlavní autoři:	Julia Smirnova, Ekaterina Kabin, Ivar Järving, Olga Bragina, Vello Tõugu, Thomas Plitz, Peep Palumaa
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2018-01-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-018-19873-2
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