Targeted degradation of aberrant Tau for the discovery of Pulsatilla chinensis in Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is characterized by Tau aggregation, mitochondrial dysfunction, and oxidative stress, yet effective interventions targeting these pathological cascades remain limited. Therapeutic strategies that enhance autophagic and mitophagic clearance, attenuate Tau...

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Detalhes bibliográficos

Principais autores:	Lan Deng, Can Yin, Xiaogang Zhou, Chi Feng, Jianming Wu, Xiaobing An, Jianing Mi, Lufen Huang, Dalian Qin, Lu Yu, Ting Chen, Anguo Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-05-01
coleção:	Chinese Medicine
Assuntos:	Alzheimer’s disease Tau Pulsatilla chinensis extract Mitophagy SH-SY5Y Caenorhabditis elegans
Acesso em linha:	https://doi.org/10.1186/s13020-025-01276-x
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