Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5
Abstract The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigation, cis‐acting genetic elements that control the...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Wiley
2022-11-01
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| Serie: | Clinical and Translational Science |
| Accesso online: | https://doi.org/10.1111/cts.13398 |
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