Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5

Abstract The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigation, cis‐acting genetic elements that control the...

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Manylion Llyfryddiaeth

Prif Awduron:	Joseph M. Collins, Adaeze C. Nworu, Somayya J. Mohammad, Liang Li, Chengcheng Li, Chuanjiang Li, Ethan Schwendeman, Mattew Cefalu, Mahmoud Abdel‐Rasoul, Jessie W. Sun, Sakima A. Smith, Danxin Wang
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Wiley 2022-11-01
Cyfres:	Clinical and Translational Science
Mynediad Ar-lein:	https://doi.org/10.1111/cts.13398
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!