Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease

Sickle cell disease (SCD) is a monogenic disorder that affects 100,000 African-Americans and millions of people worldwide. Intra-erythrocytic polymerization of sickle hemoglobin (HbS) promotes erythrocyte sickling, impaired rheology, ischemia and hemolysis, leading to the development of progressive...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Tomasz W. Kaminski, Omika Katoch, Ziming Li, Corrine B. Hanway, Rikesh K. Dubey, Adekunle Alagbe, Tomasz Brzoska, Hong Zhang, Prithu Sundd, Gregory J. Kato, Enrico M. Novelli, Tirthadipa Pradhan-Sundd
Format:	Artigo
Sprog:	Inglês
Udgivet:	Ferrata Storti Foundation 2023-11-01
Serier:	Haematologica
Online adgang:	https://haematologica.org/article/view/11337
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!