Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

Abstract The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer’s disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). However, the contribution of different cell types to Aβ deposition has not yet been exam...

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Principais autores:	Heather C. Rice, Gabriele Marcassa, Iordana Chrysidou, Katrien Horré, Tracy L. Young-Pearse, Ulrike C. Müller, Takashi Saito, Takaomi C. Saido, Robert Vassar, Joris de Wit, Bart De Strooper
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-01-01
Colecção:	Molecular Neurodegeneration
Assuntos:	Alzheimer’s disease Amyloid precursor protein Amyloid plaques APP knock-in GABAergic neurons Interneurons
Acesso em linha:	https://doi.org/10.1186/s13024-019-0356-y
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