Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

Abstract The amyloid-β (Aβ) peptide, the primary constituent of amyloid plaques found in Alzheimer’s disease (AD) brains, is derived from sequential proteolytic processing of the Amyloid Precursor Protein (APP). However, the contribution of different cell types to Aβ deposition has not yet been exam...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Heather C. Rice, Gabriele Marcassa, Iordana Chrysidou, Katrien Horré, Tracy L. Young-Pearse, Ulrike C. Müller, Takashi Saito, Takaomi C. Saido, Robert Vassar, Joris de Wit, Bart De Strooper
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2020-01-01
Schriftenreihe:	Molecular Neurodegeneration
Schlagworte:	Alzheimer’s disease Amyloid precursor protein Amyloid plaques APP knock-in GABAergic neurons Interneurons
Online-Zugang:	https://doi.org/10.1186/s13024-019-0356-y
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!