Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

Pannexin-1 ion channels on endothelial cells regulate vascular inflammation and remodeling to mediate aortic aneurysm formation. Pharmacological blockade of Pannexin-1 channels may offer translational therapeutic mitigation of aneurysmal pathology.

Bibliografiske detaljer

Principais autores:	Amanda C. Filiberto, Michael D. Spinosa, Craig T. Elder, Gang Su, Victoria Leroy, Zachary Ladd, Guanyi Lu, J. Hunter Mehaffey, Morgan D. Salmon, Robert B. Hawkins, Kodi S. Ravichandran, Brant E. Isakson, Gilbert R. Upchurch, Ashish K. Sharma
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2022-03-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-022-29233-4
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