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Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer's disease amyloid precursor protein. ADAM10 is also req...

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Principais autores: Peer-Hendrik Kuhn, Alessio Vittorio Colombo, Benjamin Schusser, Daniela Dreymueller, Sebastian Wetzel, Ute Schepers, Julia Herber, Andreas Ludwig, Elisabeth Kremmer, Dirk Montag, Ulrike Müller, Michaela Schweizer, Paul Saftig, Stefan Bräse, Stefan F Lichtenthaler
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2016-01-01
Serier:eLife
Fag:
alzheimer
metalloproteases
ADAM
mass spectrometry
bioorthogonal chemistry
Online adgang:https://elifesciences.org/articles/12748
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