Targeting polyIC to EGFR over-expressing cells using a dsRNA binding protein domain tethered to EGF.
Selective delivery of drugs to tumor cells can increase potency and reduce toxicity. In this study, we describe a novel recombinant chimeric protein, dsRBEC, which can bind polyIC and deliver it selectively into EGFR over-expressing tumor cells. dsRBEC, comprises the dsRNA binding domain (dsRBD) of...
Enregistré dans:
| Auteurs principaux: | , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science (PLoS)
2016-01-01
|
| Collection: | PLoS ONE |
| Accès en ligne: | http://europepmc.org/articles/PMC5012564?pdf=render |
| Tags: |
Pas de tags, Soyez le premier à ajouter un tag!
|