The Aβ42:Aβ40 ratio modulates aggregation in beta-amyloid oligomers and drives metabolic changes and cellular dysfunction

The pathophysiological role of Aβ42 oligomers in the onset of Alzheimer’s disease (AD) is heavily disputed, pivoting research toward investigating mixed oligomers composed of Aβ42 and Aβ40, which is more abundant but less aggregation-prone. This study investigates Aβ42:Aβ40 oligomers in different ra...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Annika Haessler, Stefanie Gier, Nathalie Jung, Maike Windbergs
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-12-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	Alzheimer’s disease Aβ oligomers blood–brain barrier Raman microscopy lipid droplets Aβ42:Aβ40
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fncel.2024.1516093/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!