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The Aβ42:Aβ40 ratio modulates aggregation in beta-amyloid oligomers and drives metabolic changes and cellular dysfunction

The pathophysiological role of Aβ42 oligomers in the onset of Alzheimer’s disease (AD) is heavily disputed, pivoting research toward investigating mixed oligomers composed of Aβ42 and Aβ40, which is more abundant but less aggregation-prone. This study investigates Aβ42:Aβ40 oligomers in different ra...

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Principais autores: Annika Haessler, Stefanie Gier, Nathalie Jung, Maike Windbergs
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-12-01
Serier:Frontiers in Cellular Neuroscience
Fag:
Alzheimer’s disease
Aβ oligomers
blood–brain barrier
Raman microscopy
lipid droplets
Aβ42:Aβ40
Online adgang:https://www.frontiersin.org/articles/10.3389/fncel.2024.1516093/full
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