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Carbamate-based cannabinoids uncover a conserved lipid-sensing pocket in nociceptive TRPA1 and TRPV1 channels

TRPA1 and TRPV1 are nociceptive ion channels that integrate noxious chemical stimuli and are attractive targets for non-opioid analgesics. The phytocannabinoids cannabidiol (CBD) and cannabigerol (CBG) modulate both channels, but their pharmacological profiles and underlying structural determinants...

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Wedi'i Gadw mewn:
Prif Awduron: Tala Amawi, Yuliya Kolesnykova, Mariana Ghantous, Alaa Nmarneh, Yana Konovalov, Nayef Ghantous, Dmitry Tsvelikhovsky, Avi Priel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2026-08-01
Cyfres:Pharmacological Research
Pynciau:
TRPA1
TRPV1
Cannabinoids
Carbamate functionalization
Ion channels
Nociception
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S1043661826002343
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