Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity

The canonical NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway involves a priming step to induce pro-IL-1β followed by a secondary signal such as K+ efflux to activate inflammasome formation. This then leads to the maturation of IL-1β and the formation of gasdermin D (GSDMD) pores...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Sarah Unterberger, Lisa Mullen, Melanie S. Flint, Sandra Sacre
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-10-01
coleção:	Frontiers in Immunology
Assuntos:	interleukin-1β (IL-1β) toll-like receptors (TLRs) NLRP3 inflammasome primary human monocytes caspase-8 gasdermin D
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1092799/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!