Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity

The canonical NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway involves a priming step to induce pro-IL-1β followed by a secondary signal such as K+ efflux to activate inflammasome formation. This then leads to the maturation of IL-1β and the formation of gasdermin D (GSDMD) pores...

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Hlavní autoři:	Sarah Unterberger, Lisa Mullen, Melanie S. Flint, Sandra Sacre
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-10-01
Edice:	Frontiers in Immunology
Témata:	interleukin-1β (IL-1β) toll-like receptors (TLRs) NLRP3 inflammasome primary human monocytes caspase-8 gasdermin D
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1092799/full
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