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Olivetol induces a non-genotoxic nucleolar DNA damage response via membrane-dependent stress signaling

Olivetol (5-pentylresorcinol) is a naturally occurring alkylresorcinol whose cellular mechanism remains poorly understood. Here, we show that olivetol induces a non-genotoxic nucleolar DNA damage response (n-DDR) in human cells. Although moderately cytotoxic, olivetol did not cause detectable genomi...

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Principais autores: Dmitry A. Deriglazov, Nadezhda V. Petrova, Artem V. Luzhin, Nataliya G. Pavlenko, Victor V. Tatarskiy, Eugene P. Kazakov, Igor I. Kireev, Alexander V. Kurkin, Anton M. Novoselov, Yuri M. Efremov, Peter S. Timashev, Sergey V. Razin, Artem K. Velichko
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2026-12-01
Serier:Nucleus
Fag:
Olivetol
nucleolar DNA damage response
ribosomal DNA
R-loops
TOPBP1
Treacle
Online adgang:https://www.tandfonline.com/doi/10.1080/19491034.2026.2672818
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