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Morphological versus spherical cellular geometry models: impact on dose-response of CA20948 cells to 177Lu- and 161Tb-labeled DOTA-TATE and DOTA-LM3

Abstract Background Accurate cellular dosimetry is essential to investigate fundamental mechanisms of targeted radionuclide therapy. The aim of this study was to assess how morphological cellular geometry models influence cellular dosimetry estimates, in comparison to simplified spherical models tha...

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Main Authors: Kaat Spoormans, Melissa Crabbé, Lara Struelens, Michel Koole
Format: Artigo
Language:Inglês
Published: SpringerOpen 2025-12-01
Series:EJNMMI Physics
Subjects:
Cell dosimetry
Morphological cell model
PRRT
SSTR2
Terbium-161
Lutetium-177
Online Access:https://doi.org/10.1186/s40658-025-00823-7
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