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Morphological versus spherical cellular geometry models: impact on dose-response of CA20948 cells to 177Lu- and 161Tb-labeled DOTA-TATE and DOTA-LM3

Abstract Background Accurate cellular dosimetry is essential to investigate fundamental mechanisms of targeted radionuclide therapy. The aim of this study was to assess how morphological cellular geometry models influence cellular dosimetry estimates, in comparison to simplified spherical models tha...

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Gardado en:
Principais autores: Kaat Spoormans, Melissa Crabbé, Lara Struelens, Michel Koole
Formato: Artigo
Idioma:Inglês
Publicado: SpringerOpen 2025-12-01
Series:EJNMMI Physics
Assuntos:
Cell dosimetry
Morphological cell model
PRRT
SSTR2
Terbium-161
Lutetium-177
Acceso en liña:https://doi.org/10.1186/s40658-025-00823-7
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