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EGFR-targeting polydopamine nanoparticles co-loaded with 5-fluorouracil, irinotecan, and leucovorin to potentially enhance metastatic colorectal cancer therapy

Abstract Despite all prevention programs, many cases of colorectal cancer (CRC) are diagnosed when they have already metastasized. Herein, chemotherapy is required, and combination of 5-fluorouracil, irinotecan, and leucovorin (FOLFIRI) is one of the first-line treatments chosen. However, it is so t...

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Principais autores: Rania Djermane, Celia Nieto, Milena A. Vega, Eva M. Martín del Valle
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-11-01
Serier:Scientific Reports
Fag:
Polydopamine nanoparticles
Colorectal cancer
5-Fluorouracil
Irinotecan
Leucovorin
Epidermal growth factor receptor
Online adgang:https://doi.org/10.1038/s41598-024-80879-0
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