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A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα

BackgroundPPARα and cyclooxygenase (COX)-2 are overexpressed in certain types of cancer. Thus, developing a dual inhibitor that targets both could be more effective as an anticancer agent than single inhibitors. We have previously shown that an analog of the bezafibrate named AA520 is a PPARα antago...

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Autori principali: Alessandra Ammazzalorso, Stefania Tacconelli, Annalisa Contursi, Ulrika Hofling, Carmen Cerchia, Sara Di Berardino, Alessandra De Michele, Rosa Amoroso, Antonio Lavecchia, Paola Patrignani
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-11-01
Serie:Frontiers in Pharmacology
Soggetti:
COX-2
PPARα
whole blood
NSAIDs
coxibs
lipidomics of eicosanoids
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2024.1488722/full
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