Mapping DNA glycosylase binding across lesion sequence contexts reveals extended sequence and structural recognition logic

Abstract DNA repair of mutagenic lesions is imperfect, allowing mutations to accumulate unevenly across the genome. In base excision repair, glycosylases must locate rare damaged bases embedded in diverse sequence contexts, yet how these contexts shape recognition and mutational outcomes remains unr...

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Autors principals:	Noga Levy, Vered Levin Salomon, Sharon N. Greenwood, Matthew Wang, Naama Kessler, Omer Erez, Brian P. Weiser, Ariel Afek
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-06-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-74090-0
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