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Enhanced sensitivity, robust p21 activation, and sustained DNA repair responses to interstrand crosslinks in elephant cells compared to humans

Elephants exhibit remarkable resistance to cancer, and understanding these mechanisms has focused on their potential applications in cancer prevention and treatment in humans. A genome-wide comparative analysis identified that the accelerated regions in elephants are enriched in Fanconi anemia (FA)...

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Principais autores: Taisuke Kitano, Zida Zhu, Naoya Minami, Koichi Orino, Yasunaga Yoshikawa
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2025-07-01
Serija:Frontiers in Veterinary Science
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Online dostop:https://www.frontiersin.org/articles/10.3389/fvets.2025.1570720/full
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