Protein kinase CK2α′ as a dual modulator of neuroimmune signaling and synaptic dysfunction in tauopathy

Abstract Background Tauopathies are a group of neurodegenerative diseases characterized by tau accumulation, neuroinflammation, and synaptic dysfunction, yet effective treatments remain elusive. Protein kinase CK2 is a holoenzyme composed of two regulatory (CK2β) and two catalytic subunits (CK2α and...

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Hlavní autoři:	Angel White, Peter Gavrilyuk, Persephone Gu, Rafael Falcon-Moya, Reid Thurston, Amal Fickak, Nicholas B. Rozema, Prarthana Keshavaram, Scott Vermilyea, Riley Schlichte, Joyce Meints, Ying Zhang, Alfonso Araque, Michael K. Lee, Rocio Gomez-Pastor
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-07-01
Edice:	Translational Neurodegeneration
Témata:	Tauopathy CK2 CK2α′ Microglia Phagocytosis Synaptic function
On-line přístup:	https://doi.org/10.1186/s40035-026-00563-3
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