Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis

Abstract Retention of metabolic end‐products in the bodily fluids of patients with chronic kidney disease (CKD) may lead to uremia. The uremic toxin indoxyl sulfate (IS), a tryptophan metabolite, is an endogenous ligand of aryl hydrocarbon receptor (AhR). It is clarified that the upregulation and ac...

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Principais autores:	Hongyan Xie, Ninghao Yang, Li Lu, Xi'ang Sun, Jingyao Li, Xin Wang, Hengjiang Guo, Li Zhou, Jun Liu, Huijuan Wu, Chen Yu, Wei Zhang, Limin Lu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2024-09-01
Series:	Advanced Science
Assuntos:	aryl hydrocarbon receptor cell senescence mitochondrial biogenesis PGC1α renal fibrosis
Acceso en liña:	https://doi.org/10.1002/advs.202402066
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