Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis

Abstract Retention of metabolic end‐products in the bodily fluids of patients with chronic kidney disease (CKD) may lead to uremia. The uremic toxin indoxyl sulfate (IS), a tryptophan metabolite, is an endogenous ligand of aryl hydrocarbon receptor (AhR). It is clarified that the upregulation and ac...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Hongyan Xie, Ninghao Yang, Li Lu, Xi'ang Sun, Jingyao Li, Xin Wang, Hengjiang Guo, Li Zhou, Jun Liu, Huijuan Wu, Chen Yu, Wei Zhang, Limin Lu
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2024-09-01
Serija:	Advanced Science
Teme:	aryl hydrocarbon receptor cell senescence mitochondrial biogenesis PGC1α renal fibrosis
Online dostop:	https://doi.org/10.1002/advs.202402066
Oznake:	Označite Brez oznak, prvi označite!